夏螢

发布时间：2013-12-09浏览次数：23352



夏螢博士

复旦特聘教授

上海市针灸机制与穴位功能重点实验室执行主任


夏螢博士，苏州医学院医学系毕业后从事临床工作近四年，其后在原上海医科大学(现复旦大学上海医学院）攻读研究生，获得医学硕士、博士学位后留校任教，担任中西医结合和神经生物学讲师。1988年赴美国耶鲁大学接受博士后训练,6年后在耶鲁大学创建自己的实验室。他于1993被耶鲁大学医学院聘为副研究员(Associate Research Scientist), 1998年晋升为研究员(Research Scientist), 2002年被聘为耶鲁大学医学院副教授(Associate Professor)。2010年在美国休斯顿德州医学中心被聘为德克萨斯州立大学研究生院教授、德克萨斯州立大学医学院教授(Full Professor)、神经外科系副主任(Vice-Chairman of the Department)和学术委员会主席(Chairman of Research and Promotion  Committee)。他于2016年受聘为复旦大学特聘教授及上海市针灸机制与穴位功能重点实验室执行主任，并兼任上海市针灸经络研究中心分子神经病学实验室主任。

夏螢博士早年的研究兴趣在于心血管调整、针刺原理、内阿片肽和其它递质的相互作用。目前，其实验室用多种现代技术研究δ-阿片受体的功能、缺血缺氧性脑损伤的保护、脑退行性疾患和针刺对神经系统疾病的影响及机理。自创建实验室至今，其课题持续获得美国国立卫生研究院、美国心脏协会、美国儿童出生缺陷基金会、美国大脑麻痹学会、美国史密斯神经病学基金会、美国赫曼基金会、中国自然科学基金委和上海市科委等机构的资助。

他多次应邀在美国国立卫生研究院、哈佛大学等世界知名医学机构以及国际会议讲学，并参与评审美国(如National Institutes of Health, US National Science Foundation, American Heart Association, US Civilian Research and Development Foundation等)、欧洲(如Scotland Medical Research of UK，Wellbeing of Women of UK，National Science Center of Poland等)和中国(如中国自然科学基金委、香港政府医药卫生基金委等)等地的科研基金和大量国际杂志的科学论文。

2020年，他和诺贝尔奖获得者屠呦呦教授等学者一起被授予首届Sheikh Zayed国际传统医学奖金质奖章。

  2021年，他被联合国工业组织全球科技创新中心授予科技创新奖。



Dr. Ying Xia

Fudan Distinguished Professor

Executive Director, Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function


Dr.Ying Xia obtained his medical training at Soochow Medical College, China. After being a clinical physician for almost 4 years, he pursued his graduate studies and obtained a Master Degree of Medicine and a Doctoral Degree of Medical Science (Ph.D.) in Neurobiology and Integrative Medicine at Shanghai Medical University (now Shanghai Medical College of Fudan University), China. Afterthen,he was appointed as a lecturer of Integrative Medicine and Neurobiology at Shanghai Medical University. Dr. Xia went to Yale University for his postdoctoral training in 1988 and initiated his laboratory at Yale in 1994. During his 22-year-long academic career at Yale University School of Medicine, he was appointed as a faculty member in 1993 and promoted to Associate Professor in 2002. From May 2010 to August 2016, he worked at the University of Texas Medical School at Houston (now the University of Texas McGovern Medical School, USA) and the University of Texas Graduate School of Biomedical Sciences at Houston as a Full Professor, Chairman of Research and Promotion Committee, and Vice-chairman for Research in the Department of Neurosurgery. He joined Fudan University as Fudan Distinguished Professor in September 2016 and serves as the Executive Director, Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function. He also serves as the Director of Molecular Neurology Laboratory at Shanghai Research Center for Acupuncture and Meridians, Shanghai, China.

Dr. Xia’s early research focused on cardiovascular regulation, acupuncture mechanism, and the interactive modulation between endogenous opioids and other neurotransmitters. His laboratory currently investigates neural functions of the delta-opioid receptor, neuroprotection against ischemic/hypoxic injury, degenerative brain disorders and acupuncture effects on neurological diseases. His research has been consecutively supported by NIH, American Heart Association, March of Dimes Foundation, Cerebral Palsy Foundation, Vivian L. Smith Neurologic Foundation and Memorial Hermann Foundation in the United States of Americas as well as National Natural Science Foundation and Science and Technology Commission of Shanghai Municipality in the People’s Republic of China since the establishment of his independent laboratory in 1994.

He has been invited to deliver speeches by many academic institutions (e.g., NIH and Harvard University) and international conferences. He has been serving as a manuscript-reviewer for many international journals and as a grant reviewer for the United States of Americas (e.g., NIH, US National Science Foundation, American Heart Association, US Civilian Research and Development Foundation), European countries (e.g., Scotland Medical Research of UK; Wellbeing of Women of UK; National Science Center of Poland) and the People’s Republic of China (e.g., Hong Kong University Grants Committees, Health & MedicalResearchFundfrom Hong Kong Government and National Natural Science Foundation of China).

In 2020, he was awarded the First Sheikh Zayed International Award for Traditional, Complementary and Alternative Medicine (TCAM), along with Professor Youyou Tu, a Nobel Laureate and other prestigious scientists in the field of TCAM.

He was awarded the Global Innovation Award of Science and Technology by UNIDO Global Science and Technology Innovation Center in 2021.




学术著作 (Academic Monographs):


    1. Xia Y. Advanced Acupuncture Research: From Bench to Bedside. Springer (New York, Heidelberg, Dordrecht, London), pp 1-779, 2022.

    2. Xia Y. Translational Acupuncture Research.Springer (Switzerland), pp 1-487, 2019.

    3. Xia Y. Neural Functions of the Delta-opioid Receptor. Springer (Heidelberg, New York, Dordrecht, London), pp 1-685, 2015.

    4. Xia Y, Ding GH, Wu GC. Current Research in Acupuncture. Springer (New York, Heidelberg, Dordrecht, London), pp 1-752, 2012.

    5. Xia Y, Cao XD, Wu GC, Cheng JS. Acupuncture Therapy for Neurological Diseases: A Neurobiological View. Springer-Tsinghua Press (Heidelberg, Beijing, Dordrecht, London, New York), pp 1-486, 2010.



2005年后代表性学术论文 (Representative Academic Articles since 2005)

*通讯作者 Corresponding author



  1. Xu Y, Chen RH, Zhi F, Sheng SY, Khiati L, Yang YL, Peng Y, Xia Y*. Delta-opioid Receptor, Microglia and Neuroinflammation. Aging and Disease, Early Access (http://www.aginganddisease.org/EN/10.14336/AD.2022.0912), 2022

    Journal Impact Factor=9.968

  2. Xu Y, Zhi F, Peng Y, Mao J, Balboni G, Yang Y and Xia Y*. A Critical Role of δ-Opioid Receptor in Anti-microglial Activation Under Stress. Front. Aging Neurosci. 14:847386, 2022.

    Journal Impact Factor=5.750

  3. Chen Y, He Y, Zhao S, He X, Xue D and Xia Y*. Hypoxic/Ischemic Inflammation, MicroRNAs and δ-Opioid Receptors: Hypoxia/Ischemia-Sensitive Versus-Insensitive Organs. Front. Aging Neurosci. 14: 847374, 2022.

    Journal Impact Factor=5.750

  4. Luo FB, Xu RF, Song GL, Xue D, He XZ, Xia Y*. Alleviation of TGF-β1 induced tubular epithelial–mesenchymal transition via the δ-opioid receptor. FEBS Journal 288(4): 1243-1258, 2021.

    Journal Impact Factor = 5.542

  5. Xu Y, Zhi F, Balboni G, Yang YL, Xia Y*. Opposite Roles of delta- and mu-Opioid Receptors in BACE1 Regulation and Alzheimer’s Injury. Frontiers in Cellular Neuroscience 14(88): 1-13, 2020.

    Journal Impact Factor = 5.505

  6. Xu Y, Zhi F, Mao JH, Peng Y, Shao NY, Balboni G, Yang YL, Xia Y*. δ-opioid receptor activation protects against Parkinson's disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy. Aging 12(257): 1-25, 2020.

    Journal Impact Factor = 5.682

  7. Chen YM, He XZ, Wang SM, Xia Y*.δ‐opioid receptors, microRNAs and neuroinflammation in cerebral ischemia/hypoxia. Frontiers in Immunology 11(421): 1-11, 2020.

    Journal Impact Factor = 7.561

  8. Luo FB, Xu RF, Song GL, Lu H, He XZ,Xia Y*. The δ-Opioid Receptor Differentially regulates MAPKs and anti-inflammatory cytokines in rat kidney epithelial cells under hypoxia. Frontiers in Physiology 10: 1-14, 2020.  

    Journal Impact Factor = 4.566

  9. Shi QQ, Xu RF, Song GL, Lu H, Xue D, He XZ*, Xia Y*. GATA3 suppresses human fibroblasts-induced metastasis of clear cell renal cell carcinoma via an anti-IL6/STAT3 mechanism. Cancer Gene Therapy 27(12): 979-982, 2020.

    Journal Impact Factor = 5.987

  10. Chen T, Wang QY, Chao DM, Xia TC, Sheng SY, Li ZR, Zhao JN, Wen GQ, Ding GH, Xia, Y*. δ-Opioid receptor activation attenuates the oligomer formation Induced by hypoxia and/or α-synuclein overexpression/mutation through dual signaling pathways. Molecular Neurobiology 56(5): 3463-3475, 2019.

    Journal Impact Factor = 5.590

  11. Xu Y, Zhi F, Peng Y, Shao NY, Khiati D, Balboni G, Yang YL, Xia Y*.  δ-Opioid receptor activation attenuates hypoxia/MPP+-induced downregulation of PINK1: A novel mechanism of neuroprotection against parkinsonism injury. MolecularNeurobiology56(1): 252-266, 2019.

    Journal Impact Factor = 5.590

  12. Chen, YM, Shi J, Xia TC, Xu RF, He XZ*, Xia Y*. Preservation Solutions for Kidney Transplantation: History, Advances and Mechanisms. Cell transplantation, 28(12): 1472-1489, 2019.

    Journal Impact Factor = 4.064

  13. Qiu J, Chao DM, Sheng SY, Khiati D, Zhou XY, Xia Y*. δ-opioid receptor-Nrf-2 mediated inhibition of inflammatory cytokines in neonatal hypoxic-ischemic encephalopathy. Molecular Neurobiology 56(7): 5229-5240, 2018.

    Journal Impact Factor = 5.590

  14. Huang JZ, Ren Y, Xu Y, Chen T, Xia TC, Li ZR, Zhao JN, Hua F, Sheng SY, Xia Y*. The delta-opioid receptor and Parkinson's disease. CNS Neuroscience Therapeutics 24(12): 1089-1099, 2018.

    Journal Impact Factor = 5.243

  15. Asakawa T, Zong L, Wang L, Xia Y, Namba H. Unmet challenges forrehabilitation after stroke in China. Lancet 390: 121-122, 2017.

    Journal Impact Factor = 79.323

  16. Asakawa T, Fang H, Sugiyama K, Nozaki T, Yang YL, Hua F, Ding GH, Hong Z, Fenoy AJ, Villarreal SJ, Chao DM, Onoe H, Suzuki K, Mori N, Namba H, Xia Y*. Animal behavioral assessments in current research of Parkinson’s disease. Neuroscience & Biobehavioral Reviews 65: 63-94, 2016.

    Journal Impact Factor = 8.989

  17. Asakawa T, Fang H, Sugiyama K, Nozaki T, Hong Z, Suzuki K, Mori N, Yang Y, Hua F, Ding G, Wen G, Namba H, Xia Y*. Human Behavioral Assessments in Current Research of Parkinson’s Disease. Neuroscience& Biobehavioral Reviews 68: 741-772, 2016.

    Journal Impact Factor = 8.989

  18. Zhou P, Chen Z, Liu X, Weng R, Liao J, Chen D, Xia Y*. Wang Q*. TLR4 signaling in MPP+-induced activation of BV2 cells. Neural Plasticity 2016: 5076740(9 pages), 2016.

    Journal Impact Factor = 3.599

  19. Chao DM, Wang Q, Balboni G, Ding G, Xia Y*. Acupuncture-induced stabilization of K+ homeostasis in rat neonatal cortex exposed to hypoxic-ischemic stress. Molecular Neurobiology 53(10): 7213-7227, 2016.

    Journal Impact Factor = 5.590

  20. Cao S, Chao DM, Zhou HH, Balboni G, Xia Y*. A novel mechanism for cytoprotection against hypoxic injury: DOR-mediated increase in Nrf2 translocation. British Journal of Pharmacology 172: 1869-1881, 2015.

    Journal Impact Factor = 8.740

  21. Xu Y, Wei X, Liu X, Liao J, Lin J, Zhou P, Zhu C, Meng X, Xie D, Chao DM, Fenoy AJ, Cheng M, Tang B, Xia Y*, Wang Q*. Low cerebral glucose metabolism: A potential predictor for the severity of vascular parkinsonism and Parkinson’s disease. Aging and Disease 6: 426-436, 2015.

    Journal Impact Factor = 6.745

  22. Jiang B, Shen RF, Bi J, Tian XS, Hinchliffe T, Xia Y*. Catalpol: A Potential Therapeutic for Neurodegenerative Diseases. Current Medicinal Chemistry 22: 1278-1291, 2015.

    Journal Impact Factor = 4.530

  23. Gao H, Wei X, Liao J, Wang R, Xu J, Liu X, Pan X, Li Z, Li Z, Xia Y*, Wang Q*. Lower bone mineral density in Patients with Parkinson’s disease: a cross-sectional study from Chinese Mainland. Frontiers in Aging Neuroscience 7: 203, 2015.

    Journal Impact Factor = 5.750

  24. Xu Y, Wei X, Liu X, Liao J, Lin J, Zhou P, Zhu C, Meng X, Xie D, Chao DM, Fenoy AJ, Cheng M, Tang B, Xia Y*, Wang Q*. Low cerebral glucose metabolism: A potential predictor for the severity of vascular parkinsonism and Parkinson’s disease. Aging and Disease 6: 426-436, 2015.

    Journal Impact Factor = 6.745

  25. Liang JF, Chao DM, Sandhu HK, Balboni G, Kim DK, Xia Y*. δ-Opioid receptors up-regulate excitatory amino acid transporters of astrocytes in the mouse brain. British Journal of Pharmacology 171: 5417-5430, 2014.

    Journal Impact Factor = 8.740

  26. Chen F, Qi ZF, Luo YM, Hinchliffe T, Ding GH, Xia Y*, Ji XM*. Non-pharmaceutical therapies for stroke: Mechanisms and clinical implications. Progress in Neurobiology 20: 191-201, 2014.

    Journal Impact Factor = 11.685

  27. Chen T, Li J, Chao DM, Sandhu HK, Liao XP, Zhao JL, Wen GQ, Xia Y*. δ-Opioid receptor activation reduces ɑ-synuclein overexpression and oligomer formation induced by MPP+ and/or hypoxia. Experimental Neurology 255:127-136, 2014.

    Journal Impact Factor = 5.330

  28. Fenoy AJ, Goetz L, Chabardès S, Xia Y*. Deep Brain Stimulation: Are Astrocytes a Key Driver Behind the Scene? CNS Neuroscience Therapeutics 20: 191-201, 2014.

    Journal Impact Factor = 5.243

  29. Wang QY, Chao DM, Xia Y*. δ-opioid receptors and inflammatory cytokines in hypoxia: Differential regulation between neuron-like and glial cells. Translational Stroke Research 5: 476-483, 2014.

    Journal Impact Factor = 6.829

  30. He XZ, Sandhu HK, Yang YL, Hua F, Belser N, Kim DH, Xia Y*. Neuroprotection against hypoxia/ischemia: δ-opioid receptor-mediated cellular/molecular event. Cellular and Molecular Life Sciences 70: 2291-2303, 2013.

    Journal Impact Factor = 9.261

  31. Chao DM, Xia Y*. From Acupuncture to interaction between delta-opioid receptors and Na+ channels: A potential pathway to inhibit epileptic hyper-excitability. Evidence-Based Complementary and Alternative Medicine 2013: Article ID 216016 (16 pages), 2013.

    Journal Impact Factor = 2.630

  32. Zhou F, Guo JC, Cheng JS, Wu GC, Sun J, Xia Y*. Electroacupuncture and brain protection against cerebral ischemia: Specific effects of acupoints. Evidence-Based Complementary and Alternative Medicine 2013: Article ID 804397 (14 pages), 2013.

    Journal Impact Factor = 2.630

  33. Zhou F, Guo JC, Cheng JS, Wu GC, Xia Y*. Effect of electroacupuncture on rat ischemic brain injury: Importance of stimulation duration. Evidence-Based Complementary and Alternative Medicine 2013: Article ID 878521 (12 pages), 2013.

    Journal Impact Factor = 2.630

  34. Kang XZ, Shen XY, Xia Y*. Electroacupuncture-induced attenuation of experimental epilepsy: A comparative evaluation of acupoints and stimulation parameters. Evidence-Based Complementary and Alternative Medicine 2012: Article ID 149612, (10 pages), 2012.

    Journal Impact Factor = 2.630

  35. Xu Y, Yan J, Zhou P, Li J, Gao H, Xia Y*, Wang Q*. Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease. Progress in Neurobiology 97(1): 1-13, 2012.

    Journal Impact Factor = 11.685

  36. Yang YL, Zhi F, He XZ, Moore ML, Kang XZ, Chao DM, Wang R, Kim DH, Xia Y*. δ-Opioid receptor activation and microRNA expression of the rat cortex in hypoxia. Plos One 7(12): e51524, 2012.

    Journal Impact Factor = 3.240

  37. Chao DM, He XZ, Yang YL, Bazzy-Asaad A, Lazarus LH, Balboni G, Kim DH, Xia Y*. DOR activation inhibits anoxic/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortex. Experimental Neurology 236 :228-239, 2012.

    Journal Impact Factor = 5.330

  38. Feng Y, He XZ, Yang YL, Chao DM, Lazarus LH, and Xia Y*. Current research on opioid receptor function. Current Drug Targets 13: 230-246, 2012.

    Journal Impact Factor = 3.465

  39. Kim JH, Song SY, Park SG, Song SU, Xia Y, Sung JH. Primary Involvement of NADPH Oxidase 4 in Hypoxia-Induced Generation of Reactive Oxygen Species in Adipose-Derived Stem Cells. Stem Cells Dev 21: 2212-2221, 2012.

    Journal Impact Factor = 6.277

  40. Chao DM, He XZ, Yang YL, Balboni G, Salvadori S, KimDH,Xia Y*. Hydrogen sulfide induced disruption of Na+ homeostasis in the cortex. Toxicological Sciences 128(1): 198~208, 2012.

    Journal Impact Factor = 4.849

  41. Park SG, Kim JH, Xia Y, Sung JH. Generation of reactive oxygen species in adipose derived stem cells: Friend or Foe? Expert Opinion on Therapeutic Targets, 15: 1297-1306, 2011.

    Journal Impact Factor = 6.902

  42. Kim JH, Park SH, Park SG, Choi JS, Xia Y, Sung JK. The Pivotal Role of Reactive Oxygen Species Generation in the Hypoxia-Induced Stimulation of Adipose-Derived Stem Cells. Stem Cells and Development 20: 1753-1761, 2011.

    Journal Impact Factor = 3.272

  43. Zhou F, Guo JC, Cheng JS, Wu GC, Xia Y*. Electroacupuncture increased cerebral blood flow and reduced ischemic brain injury: Dependence on stimulation intensity and frequency. Journal of Applied Physiology 111: 1877-1887, 2011.

    Journal Impact Factor = 3.532

  44. Chao D, Xia Y*. Ionic storm in hypoxic/ischemic stress: Can opioid receptors subside it? Progress in Neurobiology 90: 439-470, 2010.

    Journal Impact Factor = 11.685

  45. Kang XZ, Chao DM, Gu QB, Ding GH, Wang YW, Balboni G, Lazarus LH, and Xia Y*. Delta-opioid receptor activation decreases anoxic Na+ influx and K+ leakage via sodium channel regulation. Cellular and Molecular Life Sciences 66: 3505-3516, 2009.

    Journal Impact Factor = 9.261

  46. Yang YL, Xia XW, Zhang Y, Wang Q, Li L, Luo GH, Xia Y*. Delta-opioid receptor activation attenuates oxidative injury in the ischemic rat brain. BMC Biology 7: 55, 2009.

    Journal Impact Factor = 7.431

  47. Chao DM, Balboni G, Lazarus LH, Salvadori S, Xia Y*. Na+ mechanism of delta-opioid receptor induced protection from anoxic K+ leakage in the cortex. Cellular and Molecular Life Sciences 66:1105-1115, 2009.

    Journal Impact Factor = 9.261

  48. Chao DM, Bazzy-Asaad A, Balboni G, Salvadori S, and Xia Y*. Activation of DOR attenuates anoxic K+ derangement via inhibition of Na+ entry in mouse cortex. Cerebral Cortex 18: 2217-2227, 2008.

    Journal Impact Factor = 5.357

  49. Chao D, Donnelly D, Feng Y, Bazzy-Asaad A, Xia Y*. Cortical delta-opioid receptors potentiate K+ homeostasis during anoxia and oxygen-glucose deprivation. Journal of Cerebral Blood Flow and Metabolism 27: 356-368, 2007.

    Journal Impact Factor = 6.200

  50. Chao DM, Bazzy-Asaad A, Gianfranco B, Xia Y*. Delta-, but not µ-, opioid receptor stabilizes K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxia. Journal of Cellular Physiology 212: 60-67, 2007.

    Journal Impact Factor = 6.384

  51. Zhang J, Qian H, Zhao P, Hong SS, Xia Y*. Rapid hypoxia preconditioning protects cortical neurons from glutamate toxicity through delta-Opioid Receptor. Stroke 37: 1094-1099, 2006.

    Journal Impact Factor = 7.914

  52. Zhao P, Qian H, Xia Y*. GABA and glycine are protective to mature and toxic to immature in cortical neurons under hypoxia. European Journal of Neuroscience 22: 289-3000, 2005.

    Journal Impact Factor = 3.386

  53. Ma MC, Qian H, Ghassemi F, Zhao P, Xia Y*. Oxygen sensitive delta-opioid receptor-regulated survival and death signals: Novel insights into neuronal preconditioning and protection. Journal of Biological Chemistry 280: 16208-16218, 2005.

    Journal Impact Factor = 5.157